Elena Burova,Yajun Tang,Ka-Man Venus Lai,Andrew J. Murphy
申请号：
US14963402
公开号：
US20160157469A1
申请日:
2015.12.09
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a Cluster of Differentiation 274 (CD274) gene. Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous CD274 gene so that said non-human animals express a Programmed cell death ligand 1 (PD-L1) polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).
