METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING GLP-1 RECEPTOR AGONISTS CONJUGATED TO ANTAGONISTS FOR GASTRIC INHIBITORY PEPTIDE RECEPTOR (GIPR)
Yuan CHENG,Chawita NETIROJJANAKUL,Jerry Ryan HOLDER,Bin WU,James R. FALSEY,Bradley J. HERBERICH,Kelvin SHAM,Leslie P. MIRANDA,Shu-Chen LU,Murielle VENIANT-ELLISON,Shanaka STANISLAUS,Junming YIE,Jing X
申请号：
US15872841
公开号：
US20180311372A1
申请日:
2018.01.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods of treating metabolic diseases and disorders using a composition comprising an antigen binding protein specific for the GIPR polypeptide conjugated to a GLP-1 receptor agonist are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises an antibody or functional fragment thereof comprising a cysteine at one or more conjugation site(s) wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue.
