METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING GLP-1 RECEPTOR AGONISTS CONJUGATED TO ANTAGONISTS FOR GASTRIC INHIBITORY PEPTIDE RECEPTOR (GIPR)
CHENG, Yuan,NETIROJJANAKUL, Chawita,HOLDER, Jerry Ryan,WU, Bin,FALSEY, James R.,HERBERICH, Bradley J.,SHAM, Kelvin,MIRANDA, Leslie P.,LU, Shu-Chen,VENIANT-ELLISON, Murielle M.,STANISLAUS, Shanaka,YIE,
申请号：
PH12019501656
公开号：
PH12019501656A1
申请日:
2019.07.16
申请国别(地区):
PH
年份:
2019
代理人:
摘要：
Methods of treating metabolic diseases and disorders using a composition comprising an antigen binding protein specific for the GIPR polypeptide conjugated to a GLP-1 receptor agonist are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises an antibody or functional fragment thereof comprising a cysteine at one or more conjugation site(s) wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue.
