Larry R. Brown;Jennifer Machen;Terrence L. Scott;Debra Lafreniere;Vered Bisker-Leib;Nick Giannoukakis
发明人:
Larry R. Brown,Vered Bisker-Leib,Terrence L. Scott,Debra Lafreniere,Jennifer Machen,Nick Giannoukakis
申请号：
US12822774
公开号：
US09115357B2
申请日:
2010.06.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
