BAXTER INTERNATIONAL INC.;BAXTER HEALTHCARE S.A.;UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
TERRENCE L. SCOTT,DEBORAH LAFRENIERE,NICK GIANNOUKAKIS,VERED BISKER-LIEB,LARRY L. BROWN,JENNIFER MACHEN
申请号：
PT05749674
公开号：
PT1758558E
申请日:
2005.05.12
申请国别(地区):
PT
年份:
2013
代理人:
摘要：
AS-oligonucleotides are delivered in microsphere form in order to induce dendritic cell tolerance, particularly in the non-obese-diabetic (NOD) mouse model. The microspheres incorporate antisense (AS) oligonucleotides. A process includes using an antisense approach to prevent an autoimmune diabetes condition in NOD mice in vivo and in situ. The oligonucleotides are targeted to bind to primary transcripts CD40, CD80, CD86 and their combinations.
