University of Pittsburgh of the Commonwealth System of Higher Education;Baxter International Inc.;Baxter Healthcare S.A.
发明人:
Brown, Larry R.,Gillis, Kimberly A.,Giannoukakis, Nick
申请号：
AU2007281737
公开号：
AU2007281737B2
申请日:
2007.08.06
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
AS-oIigonucleotides are delivered in microsphere form in order to induce dendriticcell tolerance, particularly in the non-obese-diabetic (NOD) mouse model.The microspheres incorporate antisense (AS) oligonucleotides. A process includesusing an antisense approach to reverse an autoimmune diabetes condition in NODmice in vivo. The oligonucleotides are targeted to bind to primary transcriptsCD40, CD80, CD86 and their combinations.
