MENDES, ZITA,CACELA, CONSTANCA,TEN FIGAS, GLORIA,FERNANDEZ CASARES, ANA
申请号：
CA2975022
公开号：
CA2975022A1
申请日:
2016.02.12
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention concerns new forms of crystalline minocycline base. In particular, two new crystalline polymorphic forms, designated Form IV and Form V of minocycline base are provided. These are characterized by XRD, FTIR and TGA. Processes for preparing the new polymorphic forms and their use in pharmaceutical compositions are also provided. Form IV and form V are prepared by dissolving and/or suspending minocycline base in an organic solvent followed by crystallization.
