Zita Mendes,Constanca Cacela,Gloria Ten Figas,Ana Fernandez Casares
申请号：
US15550179
公开号：
US20180029977A1
申请日:
2016.02.12
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention concerns new forms of crystalline minocycline base. In particular, two new crystalline polymorphic forms, designated Form IV and Form V of minocycline base are provided. These are characterized by XRD, FTIR and TGA. Processes for preparing the new polymorphic forms and their use in pharmaceutical compositions are also provided. Form IV and form V are prepared by dissolving and/or suspending minocycline base in an organic solvent followed by crystallization.
