Zita Mendes,Constanca Cacela,Gloria Ten Figas,Ana Fernandez Casares
申请号：
US16041937
公开号：
US10351516B2
申请日:
2018.07.23
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Described are new forms of crystalline minocycline base. In particular, two new crystalline polymorphic forms, designated Form IV and Form V of minocycline base are provided. These are characterized by XRD, FTIR and TGA. Processes for preparing the new polymorphic forms and their use in pharmaceutical compositions are also provided. Form IV and Form V are prepared by dissolving and/or suspending minocycline base in an organic solvent followed by crystallization.
