NEW POLYMORPHIC FORMS OF MINOCYCLINE BASIS AND METHODS FOR PRODUCING THEM

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专利权人:

ХОВИОНЕ СЦИЕНТИА ЛИМИТЕД (IE)

发明人:

МЕНДИШ, Зита (PT),КАСЕЛА, Констанса (PT),ТЕН ФИГАШ, Глориа (NL),ФЕРНАНДЕС КАСАРЕШ, Ана (NL)

申请号：

RU2020101198

公开号：

RU2020101198A

申请日:

2016.02.12

申请国别(地区):

RU

年份:

2020

代理人:

摘要：

The present invention concerns new forms of crystalline minocycline base. In particular, two new crystalline polymorphic forms, designated Form IV and Form V of minocycline base are provided. These are characterized by XRD, FTIR and TGA. Processes for preparing the new polymorphic forms and their use in pharmaceutical compositions are also provided. Form IV and form V are prepared by dissolving and/or suspending minocycline base in an organic solvent followed by crystallization.

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