MONOMERIC RECOMBINANT MHC MOLECULES USEFUL FOR MANIPULATION OF ANTIGEN-SPECIFIC T CELLS

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专利权人:

OREGON HEALTH & SCIENCE UNIVERSITY

发明人:

BURROWS, GREGORY G.,VANDENBARK, ARTHUR A.

申请号：

CA2537759

公开号：

CA2537759C

申请日:

2004.09.07

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

The present invention provides, in particular embodiments, for modifiedrecombinant T cell receptor (TCR) ligands (RTLs) comprising a MHC class I orMHC class II component. The modified RTLs have redesigned surface featuresthat preclude or reduce aggregation, wherein the modified molecules retain theability to bind Ag-peptides, target antigen-specific T cells, inhibit T cellproliferation in an Ag-specific manner and have utility to treat, inter alia,autoimmune disease and other conditions mediated by antigen-specific T cellsin vivo.

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