КАСАУБОН Ребекка Л. (US),НАРАЯН Радха (US),ОУЛМАНН Кристофер (US),ВУ Чи Б. (US)
申请号：
RU2014120166/04
公开号：
RU2014120166A
申请日:
2012.10.19
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A compound represented by the structural formula (I): wherein one of D and E represents N, and the other represents C and wherein D is N, one of A and B represents N, and the other is CR and when the E represents N, B represents N and A represents N or CR or a salt thereof, wherein: each R is independently selected from hydrogen, halogen, OH, C≡N, C-Ci ^ alkyl, halogenated C-Ci ^ alkyl, C- Calkoksizameschennogo C-Ci ^ alkyl, hydroxy substituted C-Ci ^ alkyl, OR, O- (C-Ci ^ alkyl) -OR, S- (C-Ci ^ alkyl), S- (C-halogen substituted Ci ^ alkyl), N (hydroxy substituted C-Ci ^ alkyl), N (methoxy- C-Ci ^ alkyl), N (C-Ci ^ alkyl) - (hydroxy substituted C-Ci ^ alkyl), N (C-Ci ^ alkyl) (methoxy-C-Ci ^ alkyl), N (hydroxy substituted C-Ci ^ alkyl) (methoxy-C-Ci ^ alkyl), C-Ctsikloalkila and 4-8-membered nearomaticheskog heterocycle, and when one or both of the E and A are N, then R can be further selected from halogenated methyl and C-Ctsikloalkila R is an aromatic heterocycle or fused carbocyclic ring, where Rneobyazatelno substituted with one or more substituents independently selected from halogen , C≡N, C-Ci ^ alkyl, halogenated C-Ci ^ alkyl, C-C-Calkoksizameschennogo Ci ^ alkyl, hydroxy substituted C-Ci ^ alkyl, OR, O- (C-Ci ^ alkyl) -OR, = O, C-Ctsikloalkila, SOR, SR, ( C-Ci ^ alkyl) -N (R) (R), N (R) (R), O- (C-Ci ^ alkyl) -N (R) (R), O- (C-Ci ^ alkyl) -CRR (C-Ci ^ alkyl ), (C-Ci ^ alkyl) -O- (C-Ci ^ alkyl) -N (R) (R), C (= O) - N (R) (R), (C-Ci ^ alkyl) -C (= O) -N (R) (R), O- (C-Ci ^ alkyl) -CRR- (C-Ci ^ alkyl), CRR, phenyl, O- phenyl, second heterocycle, O- (second heterocycle), 3,4-methylenedioxy, halogen-substituted 3,4-methylenedioxy, 3,4-ethylenedioxy and a halogenated 3,4-ethylenedioxy, wherein any phenyl, saturated heterocycle or second heterocycle substituent in Rneobyazatelno substituted with one or bol
