HORI, AKIHIRO,堀章洋,YONEZAWA, SHUJI,米泽秀尔,米澤秀爾,FUJIKOSHI, CHIAKI,藤越千明,MATSUMOTO, SAE,松本彩枝,KOORIYAMA, YUUJI,郡山雄二,UENO, TATSUHIKO,上野达彦,上野達彥,KATO, TERUKAZU,加藤辉和,加藤輝和
申请号：
TW098119647
公开号：
TWI444378B
申请日:
2009.06.12
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention provides compounds such as the compound represented by the following formula (I) as a therapeutic agent for treating diseases induced by the production, secreation and/or deposition of amyloid β protein. The compound is represented by the formula (I):(wherein, A cycle represents carbon cyclic group optionally having substituents or heterocyclic group optionally having substituents； R1represents a lower alkyl optionally having substituents and the like； R2aand R2brepresent each independently hydrogen, a lower alkyl optionally having substituents and the like； R3aand R3crepresent each independently hydrogen, halogen, hydroxyl, a lower alkyl optionally having substituents and the like), or pharmaceutically acceptable salts thereof or their solvates.提供例如以下之化合物等作為經類澱粉β蛋白質之產生、分泌及/或沉著而誘發的疾病之治療劑。(式中，環A表示可具有取代基之碳環式基或可具有取代基之雜環式基；R1表示可具有取代基之低級烷基等；R2a及R2b各自獨立為氫、可具有取代基之低級烷基等；R3a及R3c各自獨立為氫、鹵素、羥基、可具有取代基之低級烷基等)所示化合物或其製藥上可容許的鹽或此等之溶劑化物。
