Compounds selected from the group of N-unsubstituted or N-alkylated or N-acylated 14-O-[(amino(C0-4)alkyl-hydroxy-cycloalkyl- or bicycloalkylsulfanyl)-acetyl]-mutilins which are 14-O-[(amino(C0-4)alkyl-hydroxy-cyclobutylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C0-4)alkyl-hydroxy-cyclopentylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C0-4)alkyl-hydroxy-cycloheptylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C0-4)alkyl-hydroxy-cyclooctylsulfanyl)-acetyl]-mutilins, or 14-O-[(amino(C0-4)alkyl-hydroxy-bicycloalkylsulfanyl)-acetyl]-mutilins, optionally in the form of a salt and/or a solvate, a pharmaceutical compositions comprising such compounds and their use as pharmaceuticals, e.g. for the treatment of microbial infections and for the treatment of acne, optionally in combination with other pharmaceutically active agents.本發明關於擇自N-未經取代或N-烷基化或N-醯化之14-O-[(胺基(C0-4)烷基-羥基-環烷基-或二環烷基硫基)-乙醯基]-馬替琳類中之化合物，其為14-O-[(胺基(C0-4)烷基-羥基-環丁基硫基)-乙醯基]-馬替琳，14-O-[(胺基(C0-4)烷基-羥基-環戊基硫基)-乙醯基]-馬替琳，14-O-[(胺基(C0-4)烷基-羥基-環庚基硫基)-乙醯基]-馬替琳，14-O-[(胺基(C0-4)烷基-羥基-環辛基硫基)-乙醯基]-馬替琳，或14-O-[(胺基(C0-4)烷基-羥基-二環烷基硫基)-乙醯基]-馬替琳，隨意地為鹽及/或溶劑化物之形式，亦關於含該化合物之藥學組成物以及將其用以作為藥物以隨意地與其它藥學活性劑組合以供(例如)治療微生物感染或治療痤瘡。
