Mona Saadi,Esther Duperchy,Pamela Brown,Michael John Dawson,Sjoerd Nicolaas Wadman
申请号：
US14356868
公开号：
US09234006B2
申请日:
2012.11.16
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Provided are compounds, the use of the said compounds in treatment, for example treatment of microbial infections, particularly by Gram negative bacteria. The compounds are polymyxin-based and are represented by the formula (I):and pharmaceutically acceptable salts thereof, where X is —NHC(O)—, —C(O)—, —OC(O)—, —CH2— or —SO2— R5 represents C0-12 alkyl(C4-6 heterocyclyl), or C2-12 alkyl or C0-12 alkyl(C3-8 cycloalkylyl). and the alkyl or cycloalkylyl bears one, two or three hydroxyl groups, or a —NR6R7 group, or one —NR6R7 group and one or two hydroxyl groups and R1 to R4 and R6 to R8 are as defined in the description.
