The present invention relates to compounds selected from the group consisting of 14-O-[((Mono- or dialkylamino)-cycloalkylsulfanyl- or -cycloalkyl-oxy)-acetyl, -thioacetyl or -imino-oxy]-mutilins, 14-O-[((Cycloalkyl- or heterocyclylamino)-cycloalkylsulfanyl- or -cycloalkyl-oxy)-acetyl, -thioaceyl or -imino-oxy]-mutilins, 14-O-[((Heterocyc-N-yl-cycloalkyl)-sulfanyl- or -oxy)-acetyl, -thioacetyl or -imino-oxy]-mutilins, 14-O-[(((Mono- or dialkylamino)-cycloalkyl)-alkylsulfanyl- or -alkyl-oxy)-acetyl, -thioacetyl or -imino-oxy]-mutilins, 14-O-[(((Cycloalkyl- or heterocyclylamino)-cycloalkyl)-alkylsulfanyl- or -alkyloxy)-acetyl, -thioacetyl or -imino-oxy]-mutilins, and 14-O-[((Heterocyc-N-yl-cycloalkyl)-alkylsulfanyl- or -alkyl-oxy)-acetyl, -thioacetyl or -imino-oxy]-mutilins, and their use as pharmaceuticals.本發明係關於選自由下列各化合物組成之群之化合物：14－O－[((單或二烷基胺基)－環烷基硫基－或－環烷基－氧)－乙醯基、－硫乙醯基或－亞胺基－氧]－姆替林；14－O－[((環烷基－或雜環胺基)－環烷基硫基－或－環烷基－氧)－乙醯基、－硫乙醯基或－亞胺基－氧]－姆替林；14－O－[((雜環－N－基－環烷基)－硫基－或－氧)－乙醯基、－硫乙醯基或－亞胺基－氧]－姆替林；14－O－[(((單或二烷基胺基)－環烷基)－烷基硫基－或－烷基－氧)－乙醯基、－硫乙醯基或－亞胺基－氧]－姆替林；14－O－[(((環烷基－或雜環胺基)－環烷基)－烷基硫基－或－烷基－氧)－乙醯基、－硫乙醯基或－亞胺基－氧]－姆替林；及14－O－[((雜環－N－基－環烷基)－烷基硫基－或－烷基－氧)－乙醯基、－硫乙醯基或－亞胺基－氧]－姆替林，及關於其作為藥物之用途。
