PHARMACEUTICAL COMPOSITION TO PROTECT AN ANIMAL AGAINST A DISORDER ARISING FROM AN INFECTION WITH A BACTERIUM THAT BELONGS TO THE GROUP OF NOCARDIOFORM ACTINOMYCETES农业专利-农业专业知识服务系统

发明人:: JACOBS, ANTONIUS ARNOLDUS CHRISTIAAN,约克斯安东尼斯,約克斯安東尼斯,VAN DE GEIZE, ROBERT,范德盖兹罗伯特,范德蓋茲羅伯特,DIJKHUIZEN, LUBBERT,狄克惠仁卢伯特,狄克惠仁盧伯特

摘要：: The invention pertains to a pharmaceutical composition to protect an animal against a disorder arising from an infection with a bacterium that belongs to the group of nocardioform actinomycetes having the ability to survive within macrophages of the animal, comprising live bacteria of a nocardioform actinomycetes species, the live bacteria being attenuated by inactivation of a gene that encodes a protein involved in methylhexahydroindanedione propionate degradation, and a pharmaceutically acceptable carrier for these live bacteria.本發明關於一種供動物防備由屬於諾卡菌形放線菌族群之細菌感染所引起的疾病之醫藥組成物,該諾卡菌形放線菌具有在該動物之巨噬細胞內存活之能力,該醫藥組成物包含諾卡菌形放線菌之活菌及用於該等活菌之藥學上可接受之載劑,該等活菌係經藉由使編碼涉及甲基六氫茚滿二酮丙酸酯降解之蛋白質的基因去活化而減毒。