BURNS BARBIER, Lindsay,WANG, Hoau-Yan,LIN, Nan-Horng,BLASKO, Andrei
申请号：
ES09824197
公开号：
ES2610231T3
申请日:
2009.10.30
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound or its pharmaceutically acceptable salt corresponding in structure to Formula III, in which one of Q and Z is C (O) and the other is CH2, ** Formula ** in which D and F are the same or different and are CH2, CHD or CD2, each of myn is one, W is O or NR7, X is CH2, circle A is phenyl, R1 represents up to three substituent groups that are themselves the same or different, R1a, R1b and R1c, wherein each of these three groups, R1a-c, is selected separately from the group consisting of H, C1-C6 hydrocarbyl, C1-C6 hydrocarbyloxy, C1-C6 hydrocarbyloxycarbonyl, trifluoromethyl, trifluoromethoxy, C1-C7 hydrocarboyl, hydroxy , trifluoromethyl or substituted halogen, C1-C7 hydrocarboyl, C1-C6 hydrocarbylsulfonyl, C1-C6 hydrocarbyloxysulfonyl, halogen, nitro, phenyl, cyano, carboxyl, C1-C7 hydrocarbyl carboxylate, carboxamide or sulfonamide in which the nitrogen amido in any of the groups have the formula NR3R4 in which R3 and R4 are the same or different and are H, C1-C4 h idrocarbyl, or R3 and R4 together with the represented nitrogen form a 5- to 7-membered ring that optionally contains 1 or 2 additional heteroatoms that are independently nitrogen, oxygen or sulfur, MAr, where M is -CH2-, -O- or - N>； = N- and Ar is a single ring aryl or heteroaryl group, and NR5R6 in which R5 and R6 are the same or different and are H, C1-C4 hydrocarbyl, C1-C4 acyl, C1-C4 hydrocarbylsulfonyl, or R5 R6 together with the represented nitrogen form form a 5 to 7 member ring optionally containing 1 or 2 additional heteroatoms that are independently nitrogen, oxygen or sulfur； R2 is H, C1-C6 hydrocarbyl, and R7 is H, C (H) v (D) h where each of v and h is 0, 1, 2 or 3 and v + h>； = 3, C (H) q ( D) r-aliphatic C1-C11 hydrocarbyl, where each of qyr is 0, 1, or 2 and q + r>； = 0, 1 or 2, -aliphatic C1-C12 hydrocarbyl sulfonyl or C1-C12 aliphatic hydrocarboyl； provided that the compound is not: ** Formula **Un compuesto o su sal farmacéuticamente aceptable que corresponde en estructu
