Andrew FENSOME,Ariamala GOPALSAMY,Brian S. GERSTENBERGER,Ivan Viktorovich EFREMOV,Zhao-Kui WAN,Betsy PIERCE,Jean-Baptiste TELLIEZ,John I. TRUJILLO,Liying ZHANG,Li XING,Eddine SAIAH
申请号：
US16580667
公开号：
US20200038409A1
申请日:
2019.09.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A compound having the structure:or a pharmaceutically acceptable salt thereof, wherein X is N or CR, where R is hydrogen, deuterium, C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, aryl, heteroaryl, aryl(C1-C6 alkyl), CN, amino, alkylamino, dialkylamino, CF3, or hydroxyl； A is selected from the group consisting of a bond, C═；O, —；SO2—；, —；(C═；O)NR0—；, and —；(CRaRb)q—；, where R0 is H or C1-C4 alkyl, and Ra and Rb are independently hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, aryl(C1-C6 alkyl), heteroaryl, (C1-C6 alkyl)heteroaryl, etc.； A′； is selected from the group consisting of a bond, C═；O, —；SO2—；, —；(C═；O)NR0′；, —；NR0′；(C═；O)—；, and —；(CRa′；Rb′；)q—；, where R0′； is H or C1-C4 alkyl, and Ra′； and Rb′； are independently hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, aryl(C1-C6 alkyl), heteroaryl, (C1-C6 alkyl)heteroaryl, heteroaryl(C1-C6 alkyl), and heterocyclic(C1-C6 alkyl)； Z is —；(CH2)h—； or a bond, where one or more methylene units are optionally substituted by one or more C1-C3 alkyl, CN, OH, methoxy, or halo, and where said alkyl may be substituted by one or more fluorine atoms； R1 and R1′； are independently selected from the group consisting of hydrogen, deuterium, C1-C4 alkyl, C3-C6 cycloalkyl, aryl, heteroaryl, aryl(C1-C6 alkyl), CN, etc., wherein said alkyl, aryl, cycloalkyl, heterocyclic, or heteroaryl is further optionally substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, halo, CN, C1-C4 alkylamino, C3-C6 cycloalkyl, etc.； R2 is selected from the group consisting of hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, halo, and cyano, where said alkyl may be substituted by one or more fluorine atoms； R3 is selected from the group consisting of hydrogen, deuterium, and amino； R4 is monocyclic or bicyclic aryl or monocycli
