The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I):wherein R1represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X1represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y1represents -C(O)-, -S(O)- or -S(O)2-, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X2represents a bond or an optionally substituted lower alkylene, Y2represents -C(O)-, -S(O)-, -S(O)2- or -C(=NR7)-, X3represents an optionally substituted C1-4alkylene or an optionally substituted C2-4alkenylene, Z3represents -N(R4)-, -O- or a bond, Z1represents -C(R2)(R2)-, -N(R2)-, etc., and Z2represents -C(R3)(R3)-, -N(R3)-, etc., or a salt thereof.本發明提供一種可作為治療血栓形成(thrombosis)之藥物之環狀醯胺衍生物或其鹽,其係以式(I)表示:其中R1代表視需要經取代之環狀烴基或視需要經取代之雜環基,W代表鍵結或視需要經取代之二價鏈烴基,a代表0、1、或2,X1代表視需要經取代之低碳數伸烷基或視需要經取代之低碳數伸烯基,Y1代表-C(O)-、-S(O)-或-S(O)2-,A代表可進一步經取代之六氫吡環或代表可進一步經取代之六氫吡啶環,X2代表鍵結或視需要經取代之低碳數伸烷基,Y2代表-C(O)-、-S(O)-、-S(O)2-或-C(=NR7)-,X3代表視需要經取代之C1-4伸烷基或視需要經取代之C2-4伸烯基,Z3代表-N(R4)-、-O-或鍵結,Z1代表-C(R2)(R2’)-、-N(R2)-等,以及Z2代表-C(R3)(R3’)-、-N(R3)-等。
