FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula Iwherein R is H； R' is C1-6 alkoxy or or R and R' together form 4-membered heterocycloalkyl having one nitrogen atom as a ring heteroatom optionally substituted with -CN； R1 is H or R1a； R1a is C1-6alkyl, C3-8cycloalkyl, C1-6alkoxy, hydroxy-C1-6alkyl or halogen-C1-6alkyl； R1 is H or C1-6alkyl； or R1a and R1' together form 4-6-membered heterocycloalkyl containing one ring heteroatom selected from N, O and S(=O)2, C3-8cycloalkyl, indan-1-yl or phenyl optionally substituted with one or more R1"； each R1" is independently hydroxy, amino, oxo, C1-6alkyl, -C(=O)NH2, -CN, halogen-C1-6alkyl, benzyl, cyano-C1-6alkyl or -NHC(=O)OC(CH3)3； R2 is H, hydroxy, -CN, -C(=O)OH, -C(=O)OC(CH3)3, R2a or R2b； R2a is C1-6alkyl, phenyl, phenyl-C1-6alkyl, C3-8cycloalkyl, heteroaryl, heterocycloalkyl, heterocycloalkyl-C1-6alkyl, heteroaryl-C1-6alkyl, phenyl-C1-6alkoxy, C1-6alkoxy optionally substituted by one or more R2a', wherein heteroaryl is selected from oxazolyl, isoxazolyl, 4,5-dihydro-oxazolyl, pyridinyl, imidazolyl and pyrazolyl, and wherein heterocycloalkyl is selected from tetrahydrofuranyl, azetidinyl, oxetanyl, pyrrolidinyl and tetrahydropyranyl； each R2a' is independently hydroxy, -CN, amino, C1-6alkyl-sulfonylamino, C1-6alkoxy, halogen atom, C1-6alkyl, cyano-C1-6alkyl, halogen-C1-6alkyl, C1-6alkyl-sulfonyl, halogen-C1-6alkoxy, C3-8cycloalkyl； R2b is -C(=O)R3 or -CH2C(=O)R3； R3 is heterocycloalkyl selected from piperidinyl, azetidinyl, 2-oxa-6-aza-spiro[3.3]heptyl, morpholinyl and pyrrolidinyl optionally substituted with one or more R3'； each R3' is independently -CN, a halogen atom or C1-6alkyl； Q is 1H-indazol-3-yl, 4,5,6,7-tetrahydro-1H-indazol-3-yl, 1H-indol-3-yl, 5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl, imidazo[1,5-a]pyridin-1-yl, indazol-1-yl, 1H-pyrazolo[3,4-b]pyridin-3-yl, 1H-pyrazolo[4,3-b]pyridin-3-yl, imidazo[1,2-a]pyridin-3-yl, 2-hydroxy-4,5,6,7-tetrahydro-1H-indazol-3-yl, benzoimidazol-1-yl
