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HETEROARIL-CONDENSED ACCESSED CYCLLOCHYLAMINES AND THEIR USE AS PHARMACEUTICAL COMPOUNDS.
专利权人:
SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人:
STROBEL, HARTMUT,WOHLFART, PAULUS
申请号:
ES03784055
公开号:
ES2373651T3
申请日:
2003.07.24
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of formula I in any of its stereoisomeric forms or one of its mixtures in any ratio, or one of its pharmaceutically acceptable salts, wherein in formula I: ring A, which comprises the two carbon atoms common to the ring A and the cycloalkenyl ring in formula I, is a 5 or 6 membered aromatic ring containing 1 or 2 nitrogen atoms as ring heteroatoms, or a 5 member aromatic ring containing 1 ring heteroatom which is a oxygen or sulfur atom, or 2 heteroatoms in the ring, one of which is a nitrogen atom and another of which is an oxygen or sulfur atom; R1 and R4 are independently selected from each other from the group consisting of: an atom of H; a C1-C10 alkyl group, a C2-C10 alkenyl group and an unsubstituted and at least monosubstituted C2-C10 alkynyl group, the substituents of which are selected from the group consisting of an atom of F, an OH group , a C1-C8 alkoxy group, a C1-C8-mercapto alkyl group, a -CN group, a COOR6 group, a CONR7R8 group, and unsubstituted and at least monosubstituted phenyl and heteroaryl groups in which the substituents of the phenyl and heteroaryl groups are selected from the group consisting of a halogen atom, a -CN group, a C1-C3 alkyl group, a C1-C3 alkoxy group and a CF3 group; unsubstituted and at least monosubstituted phenyl and heteroaryl groups, whose substituents are selected from the group consisting of a halogen atom, a -CN group, a C1-C3 alkyl group, a C1-C3 alkoxy group and a CF3 group; a COR9 group; a CONR10R11 group; a COOR12 group; a CF3 group; a halogen atom; a group - CN; an NR13R14 group; an OR15 group; an S (O) group mR16; a group SO2NR17R18; and a NO2 group; but they cannot be a halogen atom, a -CN group or a NO2 group if R1 or R4 are linked to a ring nitrogen atom; R2 and R3 are independently selected from each other from the group consisting of: an atom of H; a halogen atom; a group -CN; an unsubstituted and at least monosubstituted C1-C10 alkyl group, whose substituents are selected from the group consis
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