KIM, Charles,NAKAI, Takashi,LEE, Thomas Wai-ho,MOORE, Joel,PERL, Nicholas Robert,ROHDE, Jason
申请号：
ES11784873
公开号：
ES2572803T3
申请日:
2011.11.02
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound according to Formula IA or IB, or a pharmaceutically acceptable salt thereof, ** Formula ** wherein the symbol with the surrounding letter 5 B represents ring B, and ring B is a phenyl or a heteroaryl ring of 6 members, containing 1 or 2 ring atoms of nitrogen； n is an integer selected from 0 to 3； each JB is independently selected from halogen, -CN, -NO2, a C1-6 aliphatic group, -ORB or a C3-8 cycloaliphatic group； wherein each said C1-6 aliphatic group and each said C3-8 cycloaliphatic group is optionally and independently substituted with up to 3 examples of R3； each RB is independently selected from hydrogen, a C1-6 aliphatic group or a C3-8 cycloaliphatic group； wherein each said C1-6 aliphatic group and each said C3-8 cycloaliphatic ring is optionally and independently substituted with up to 3 examples of R3； each R3 is independently selected from halogen, -CN, C1-4 alkyl, C1-4 haloalkyl, -O (C1-4 alkyl) or -O (C1-4 haloalkyl)； X is selected from N, C-H or C, and is optionally substituted by JD when X is N or C； Ring D is the 6-member ring that has X in Formula IA or the 5-member ring that has Y in Formula IB； each Y is independently selected from C-H, C, N, O or S, and is optionally substituted by JD when Y is C or N； each of the bonds between two adjacent Y atoms or between adjacent Y and N in Formula IB is independently a single or double bond depending on whether Y is C, N, O or S； m is an integer selected from 0 to 3； each JD is a substituent on a carbon or nitrogen ring atom and is independently selected from halogen, -NO2, -ORD, -SRD, -C (O) RD, -C (O) ORD, -C (O) N ( RD) 2, -CN, -N (RD) 2, -N (Rd) C (O) RD, -N (Rd) C (O) ORD, -SO2RD, -SO2N (RD) 2, -N (Rd ) SO2RD, a C1-6 aliphatic group, - (C1-6 aliphatic) -RD, a C3-8 cycloaliphatic ring, a 6 to 10 membered aryl ring, a 4 to 8 membered heterocyclic ring or a 5 to 8 heteroaryl ring to 10 members； wherein each said 4 to 8-membered heterocyclic ring and each said 5 to 10-membered heteroaryl ring
