FAN, Junfa,KRASINSKI, Antoni,LANGE, Christopher W.,LUI, Rebecca M.,MCMAHON, Jeffrey P.,POWERS, Jay P.,ZENG, Yibin,ZHANG, Penglie
申请号：
ES13859147
公开号：
ES2681593T3
申请日:
2013.11.26
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound having the formula I ** Formula ** or a pharmaceutically acceptable salt, hydrate, N-oxide, isotopically enriched or enantiomerically enriched version and a rotamer thereof in which each of the vertices of the ring Xa, Xb and Xc is independently selected from the group consisting of N, NH, N (R2), CH and C (R2)； the subscript n is 0, 1 or 2； Z is selected from the group consisting of (i) condensed monocyclic or bicyclic aryl and heteroaryl, wherein the heteroaryl group has 1-4 heteroatoms as ring members selected from N, O and S； and wherein said aryl and heteroaryl groups are optionally substituted with 1 to 5 R5 substituents； (ii) monocyclic ring of four, five, six or seven members selected from the group consisting of cycloalkane, and heterocycloalkane, wherein the heterocycloalkane rings have 1-3 heteroatoms as selected ring members of N, O and S； and wherein each of said monocyclic Z rings are optionally substituted with 1 to 3 R5 substituents； R1 is a member selected from the group consisting of H and C1-8 alkyl, wherein the alkyl portion is optionally substituted with halogen, -NRaRb, -ORa, -CO2Ra, and -CONRaRb； each R2 is independently selected from the group consisting of H, halogen, CN, C1-8 alkyl, C1-8 haloalkyl, C1-8 hydroxyalkyl, -ORa, -CO2Ra, -X-CO2Ra, -NRaRb, -CONRaRb and -X -CONRaRb； R3 is a member selected from the group consisting of H, C1-8 alkyl, C1-8 haloalkyl, C1-8 hydroxyalkyl, - CO2Ra, -X-CO2Ra, -CONRaRb and -X-CONRaRb； each R4, when present, is a member independently selected from the group consisting of C1-8 alkyl, C1-8 haloalkyl, C1-8 hydroxyalkyl, -ORa, -CO2Ra, -X-CO2Ra, -NRaRb, -CONRaRb and - X-CONRaRb； each R5 is a member independently selected from the group consisting of halogen, CN, -X-CN, C1-8 alkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C3-5 spirocycloalkyl, C2-8 alkenyl, C2-8 alkynyl , C1-8 haloalkyl, C1-8 hydroxyalkyl, -ORa, -CO2Ra, -X-CO2Ra, -NRaRb, -CONRaRb, -X-CONRaRb, aryl, 5- or 6-membered heteroaryl and 3, 4, 5 or
