A compound having the formula ** Formula ** or a pharmaceutically acceptable salt, hydrate or rotomer thereof； where C1 is selected from the group consisting of aryl and heteroaryl, where the heteroaryl group has 1-3 heteroatoms as ring members selected from N, O and S； and wherein said aryl and heteroaryl groups are optionally substituted with 1 to 3 R1 substituents； C2 is selected from the group consisting of aryl and heteroaryl, where the heteroaryl group has between 1-3 heteroatoms as ring members selected from N, O and S； and wherein said aryl and heteroaryl groups are optionally substituted with 1 to 3 R2 substituents； C3 is selected from the group consisting of C1-8 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-4 alkyl, aryl, aryl-C1-4 alkyl, heteroaryl, heteroaryl-C1-4 alkyl, heterocycloalkyl or heterocycloalkyl C1-4alkyl, where the heterocycloalkyl group or portion has between 1-3 heteroatoms selected from N, O and S, where the heteroaryl group has between 1-3 heteroatoms as ring members selected from N, O and S, and each C3 is optionally substituted with between 1-3 R3 substituents； each R1 is independently selected from the group consisting of halogen, -CN, -Rc, -CO2Ra, -CONRaRb, -C (O) Ra, -OC (O) NRaRb, -NRbC (O) Ra, -NRbC (O ) 2Rc, -NRa-C (O) NRaRb, -NRaC (O) NRaRb, -NRaRb, -ORa, and -S (O) 2NRaRb； where each Ra and Rb is independently selected from hydrogen, C1-8 alkyl, and C1-8 haloalkyl, or when attached to the same nitrogen atom can be combined with the nitrogen atom to form a five or six membered ring having 0 to 2 additional heteroatoms as ring members selected from N, O or S； each Rc is independently selected from the group consisting of C1-8 alkyl, C1-8 haloalkyl, C3-6 cycloalkyl, heterocycloalkyl, aryl and heteroaryl, and where the aliphatic and cyclic portions of Ra, Rb and Rc are further optionally substituted with from one to three halogen, hydroxy, methyl, amino, alkylamino and dialkylamino groups； and optionally when two R1 substituents are
