An oil-in-water formulation for the inhibition of the transmission of sexually transmitted pathogens, characterized by improved skin protective properties consisting of a combination of: (1) dimethicone 20, in the range of 10.0 to 20.0% w / w ; (2) dimethicone 12500, in the range of 3.0-10.0% w / w; (3) zinc oxide, in the range of 1.0 to 8.0% w / w; (4) a mixture of cetearyl alcohol and ceteareth-20, in the range of 6.0 to 10.0% w / w; (5) glycerin, in the range of 2.0 to 10.0% w / w; (6) ceteareth-12, in the range of 0.5 to 3.0% w / w; (7) disodium edetate, in the range of 0.01 to 0.1% w / w; (8) benzalkonium chloride, in the range of 0.01 to 0.25% w / w; (9) anhydrous lanolin, in the range of 0.5 to 3.0% w / w; (10) ketostearyl alcohol, in the range of 1.0 to 5.0% w / w; (11) cetyl alcohol, in the range of 1.0 to 5.0% w / w; and (12) a sufficient amount of deionized water to form the formulation; wherein contact with the skin results in the in situ formation of a protective barrier layer of the skin and wherein said sexually transmitted pathogens are viral pathogens.Una formulación de aceite en agua para la inhibición de la transmisión de patógenos de transmisión sexual, caracterizado por propiedades protectoras de la piel mejoradas que consisten en una combinación de: (1) dimeticona 20, en el intervalo de 10.0 a 20.0% p/p; (2) dimeticona 12500, en el intervalo de 3.0-10.0% p/p; (3) óxido de zinc, en el intervalo de 1.0 a 8.0% p/p; (4) una mezcla de alcohol cetearílico y ceteareth-20, en el intervalo de 6.0 a 10.0% p/p; (5) glicerina, en el intervalo de 2.0 a 10.0% p/p; (6) ceteareth-12, en el intervalo de 0.5 a 3.0% p/p; (7) edetato disódico, en el intervalo de 0.01 a 0.1% p/p; (8) cloruro de benzalconio, en el intervalo de 0.01 a 0.25% p/p; (9) lanolina anhidra, en el intervalo de 0.5 a 3.0% p/p; (10) alcohol cetoestearílico, en el intervalo de 1.0 a 5.0% p/p; (11) alcohol cetílico, en el intervalo de 1.0 a 5.0% p/p; y (12) una cantidad suficiente de agua desion