Disclosed is an oil-in-water cream emulsion suitable for the prevention of sexually transmitted diseases, characterized by enhanced skin protective properties consisting of in combination: (1) dimethicone 20 (i.e. a polydimethylsiloxane derivative), in the range of 10.0 to 20.0 % wt/wt； (2) dimethicone 12500, in the range of 3.0-10.0 % wt/wt； (3) zinc oxide, in the range of 1.0 to 8.0 % wt/wt； (4) a mixture of cetearyl alcohol and ceteareth-20, in the range of 6.0 to 10.0 % wt/wt； (5) glycerin, in the range of 2.0 to 10.0 % wt/wt； (6) ceteareth-12, in the range of 0.5 to 3.0 % wt/wt； (7) disodium edetate, in the range of 0.01 to 0.1 % wt/wt； (8) benzalkonium chloride, in the range of 0.01 to 0.25 % wt/wt； (9) anhydrous lanolin, in the range of 0.5 to 3.0 % wt/wt； (10) cetostearyl alcohol, in the range of 1.0 to 5.0 % wt/wt； (11) cetyl alcohol, in the range of 1.0 to 5.0 % wt/wt； and (12) a sufficient quantity of deionized water to form the cream； and wherein said cream is formulated such that on contact with the skin a skin protective barrier layer is formed. (61) Addition to 600568
