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Synthèse du monosuccinate de la solifénacine
专利权人:
ASTELLAS PHARMA INC.
发明人:
申请号:
EP10191324.2
公开号:
EP2305676B1
申请日:
2005.04.25
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
There is provided a novel method for producing solifenacin or a salt thereof which is useful as a medicine, particularly a therapeutic agent and/or a preventive agent for a urinary organ system disease such as pollakiuria or urinary incontinence. Illustratively, there are provided (1) a method for producing solifenacin in which 2-(1H-imidazolylcarbonyl)-1-phenyltetrahydroisoquinoline is used as the starting material, (2) a method for producing solifenacin succinate in which (1RS)-phenyltetrahydroisoquinoline-carboxylic acid quinuclidinyl ester is used as the starting material, (3) a method for producing solifenacin in which a lower alkyl quinuclidinyl carbonate is used as the starting material and (4) a method for producing solifenacin in which phenyltetrahydroisoquinoline-carboxylic acid secondary lower alkyl or tertiary lower alkyl ester is used as the starting material and allowed to react with an alkali metal lower alkoxide.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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