Улитин Андрей Борисович (RU),Евдокимов Станислав Рудольфович (RU),Соловьев Валерий Владимирович (RU),Черных Юлия Сергеевна (RU),Гончарова Ольга Владимировна (RU),Коржавин Дмитрий Валерьевич (RU),Черно
申请号：
RU2014109854/10
公开号：
RU2014109854A
申请日:
2014.03.14
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The selected monoclonal antibody that specifically binds to human IL-17A, or a fragment thereof containing the variable regions of the heavy chain (V) and light chain (V), where the specified antibody or fragment thereof contains: a) the variable domain of the heavy chain (V) an antibody that contains 3 hypervariable regions of HCDR1, HCDR2 and HCDR3, where HCDR1 includes the amino acid sequence represented by SEQ ID NO: 1: FTFS-X31-X32-X33-X34-X35 (according to Kabat nomenclature), where X31 is an amino acid selected from the group including N, D, K, L, P or T； X32 is th amino acid selected from the group consisting of Y and F； X33 is an amino acid selected from the group consisting of A, G, N, S, T or V； X34 is an amino acid selected from the group comprising M and I； X35 is is an amino acid selected from the group consisting of S, G, N or T； HCDR2 includes the amino acid sequence of SEQ ID NO: 2: X50-I-X52-X52a-X52b-X53-G-X55-X56-X57-X58X50 is an amino acid selected from the group consisting of R, G, I, L, M, and S； X52 is an amino acid selected from the group consisting of D and E； X52a is amino acids a slot selected from the group consisting of G and M； X52b is an amino acid selected from the group comprising G, L, R and V； X53 is an amino acid selected from the group comprising I and L； X55 is an amino acid selected from a group comprising S, T, L, R and W； X56 is an amino acid selected from the group comprising S, T, S and Y； X57 is an amino acid selected from the group comprising S, T, L, R and W ； X58 is an amino acid selected from the group consisting of Y, T, L, and K； HCDR3 includes an amino acid sequence1. Выделенное моноклональное антитело, специфически связывающееся с IL-17А человека, или его фрагмент, содержащий вариабельные области тяжелой цепи (V) и легкой цепи (V),где указанное антитело или его фрагмент содержит:а) вариабельный домен тяжелой цепи (V) антитела, который содержит 3 гипервариабельных участка HCDR1, HCDR2 и HCDR3, гдеHCDR1 включает
