BRAVO GONZALEZ, ROBERTO CARLOS,BUSER, THOMAS,GOUTTE, FREDERIC JEAN-CLAUDE,BASIT, ABDUL WASEH,VARUM, FELIPE JOSE OLIVERIA,FREIRE, ANA CRISTINA
申请号：
PE0017792014
公开号：
PE24422014A1
申请日:
2013.04.29
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Referring to a delayed release oral formulation comprising a Core and a Coating for the core, the core comprising a Drug and the coating comprises an inner layer and an outer layer, the outer layer comprising a mixture of a First polymeric material that is suscept Possible attacks by The Colonic bacteria,And a Second polymeric material that has a pH Threshold to approximately pH 5 or higher, and the Third Inner Layer comprises a Polymer that is Soluble in the intestinal Fluid or Fluid in the gastrointestinal, such third polymeric material is selected from the policarboxilico acid me We partially neutralized and a nonionic Polymer.In modalities where the Third polymeric material is a nonionic Polymer, The Inner Layer comprises at least a buffering Agent and a base. The Insulating Layer comprises a nonionic Polymer which is Soluble in the gastrointestinal intestinal Fluid or Fluid.The advantages of the formulations of the invention include the Rapid Release of the drug when exposed to conditions colonic and the reduction or elimination of the effect of Food and \/ or alcohol in the drug Release after AdministrationReferida a una formulacion oral de liberacion retardada que comprende un nucleo y un recubrimiento para el nucleo, el nucleo comprende un farmaco y el recubrimiento comprende una capa interior y una capa exterior, la capa exterior comprende una mezcla de un primer material polimerico que es susceptible a ataques por parte de la bacteria colonica, y un segundo material polimerico que tiene un umbral de pH a aproximadamente pH 5 o mas alto y la capa interior comprende un tercer material polimerico que es soluble en el fluido intestinal o en el fluido gastrointestinal, tal tercer material polimerico se selecciona de acido policarboxilico al menos parcialmente neutralizado y un polimero no ionico. En modalidades en donde el tercer material polimerico es un polimero no ionico, la capa interior comprende al menos un agente amortiguador y una base. La capa de aisla
