BRAVO GONZALEZ, ROBERTO CARLOS,BUSER, THOMAS,GOUTTE, FREDERIC JEAN-CLAUDE,BASIT, ABDUL WASEH,VARUM, FELIPE JOSE OLIVERIA,FREIRE, ANA CRISTINA
申请号：
PE2014001779
公开号：
PE20142442A1
申请日:
2013.04.29
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
The oral formula for delayed release includes a nucleon and a nuclear coating, the nucleon includes a pharmacy, the coating includes an inner layer and an outer layer, and the shell includes a mixture of the first polygonal substance, which is vulnerable to coliform attack, The second polygonal substance has a pH value of about pH 5 or higher. The inner layer is composed of a third polygonal substance, which can be dissolved in intestinal fluid or gastrointestinal fluid,A third polymer material is selected from at least partially neutralized polycarbonate and nonionized daughter polymers. In the case where the third polymer is a nonionized daughter polymer, the inner layer includes at least one buffer and one substrate. The insulating layer includes a non ionizing polymer that can be dissolved in intestinal fluid or gastrointestinal fluid. According to the present invention, the benefits of a formula include the rapid release of a pharmacy when it is exposed to colonial conditions, and the reduction or elimination of the effects of food and / or alcohol on the release after pharmacy management.Referida a una formulacion oral de liberacion retardada que comprende un nucleo y un recubrimiento para el nucleo, el nucleo comprende un farmaco y el recubrimiento comprende una capa interior y una capa exterior, la capa exterior comprende una mezcla de un primer material polimerico que es susceptible a ataques por parte de la bacteria colonica, y un segundo material polimerico que tiene un umbral de pH a aproximadamente pH 5 o mas alto y la capa interior comprende un tercer material polimerico que es soluble en el fluido intestinal o en el fluido gastrointestinal, tal tercer material polimerico se selecciona de acido policarboxilico al menos parcialmente neutralizado y un polimero no ionico. En modalidades en donde el tercer material polimerico es un polimero no ionico, la capa interior comprende al menos un agente amortiguador y una base. La capa de aislamiento comprende un
