BRAVO GONZALEZ ROBERTO CARLOS,BUSER THOMAS,GOUTTE FREDERIC JEAN-CLAUDE,FREIRE ANA CRISTINA,VARUM FELIPE JOSÉ OLIVERIA,BASIT ABDUL WASEH
申请号：
CO14260651
公开号：
CO7151506A2
申请日:
2014.11.26
申请国别(地区):
CO
年份:
2014
代理人:
摘要：
The core consists of a drug and a coating, containing a layer, and at least one layer between the core and the selected outer layer within the group, containing an insulating layer. The shell consists of a mixture of the first and second polybrominated diphenyl ethers, which may be attacked by Columbus bacteria, with a pH value of about pH 5 or higher. The inner layer consists of a third kind of Dominic substance, which can be dissolved in intestinal fluid or gastrointestinal fluid,The third polybrominated diphenyl ether is selected from at least partially neutralized polycarbonate and nonionic polymers. In the case where the third PBDE is a non-ionic polymer, the inner layer includes at least one buffer and one substrate. The insulating layer is composed of non-ionic polymer, which can be dissolved in intestinal fluid or gastrointestinal fluid. The appearance is a kind of water medium, the second kind of polybrominated diphenyl ether in the organic environment. LThe advantages of the formula according to the present invention include: accelerating the release of the drug when the drug is in a dangerous state, reducing or eliminating the influence of food and / or alcohol on the taking of the drug.El núcleo comprende un fármaco y un recubrimiento que comprende una capa interior y al menos una capa entre el núcleo y la capa exterior seleccionada del grupo que consiste de una capa de aislamiento y una capa interior. La capa exterior comprende una mezcla de un primer material polimèrico que es susceptible a ataques por parte de la bacteria colònica, y un segundo material polimèrico que tiene un umbral de pH a aproximadamente pH 5 o más alto. La capa interior comprende un tercer material polimèrico que es soluble en el fluido intestinal o en el fluido gastrointestinal, tal tercer material polimèrico se selecciona de ácido policarboxíNco al menos parcialmente neutralizado y un polimero no iónico. En modalidades en donde el tercer material polimèrico es un polimero no ión
