Ryan White,Albert Amegadzie,Marian C. Bryan,Jian Jeffrey Chen,Alan C. Cheng,Thomas Dineen,Oleg Epstein,Vijay Keshav Gore,Zihao Hua,Jason Brooks Human,Hongbing Huang,Charles Kreiman,Daniel La,Qingyian
申请号：
US12558426
公开号：
US08426447B2
申请日:
2009.09.11
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimers disease (AD) and related conditions. In one embodiment, the compounds have a general Formula Iwherein A1, A2, A3, A4, A5, A6, T1, T2, W, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimers Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
