Charles Kreiman,Chester C. Yuan,Daniel La,Hongbing Huang,Isaac Marx,Jason B. Human,Matthew Weiss,Qingyian Liu,Ryan White,Vinod F. Patel,Vu Van Ma,Wenyuan Qian
申请号：
BRPI0918449
公开号：
BRPI0918449A2
申请日:
2009.09.11
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, T1, T2, W, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
