Chen, Yuan,White, Ryan,Amegadzie, Albert,Brown, James,Cheng, Alan C.,Dimauro, Erin F.,Dineen, Thomas,Epstein, Oleg,Gore, Vijay Keshav,Human, Jason Brooks,Judd, Ted,Kreiman, Charles,Liu, Qingyian,Lopez
申请号：
AU2011227511
公开号：
AU2011227511A1
申请日:
2011.03.14
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula (I) wherein A, A, A, A, A, A, R, R, X and Y of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
