Yuan Cheng;Jason Brooks Human;Albert Amegadzie;James Brown;Oleg Epstein;Patricia Lopez;Erin F. Dimauro;Vijay Keshav Gore;Ryan White;Alan C. Cheng;Ted Judd;Qingyian Liu;Thomas Dineen;Charles Kreiman;Vu
发明人:
Yuan Cheng,Ryan White,Albert Amegadzie,James Brown,Alan C. Cheng,Erin F. Dimauro,Thomas Dineen,Oleg Epstein,Vijay Keshav Gore,Jason Brooks Human,Ted Judd,Charles Kreiman,Qingyian Liu,Patricia Lopez,Vu
申请号：
US13047734
公开号：
US08883782B2
申请日:
2011.03.14
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula Iwherein A1, A2, A3, A4, A5, A6, R2, R7, X and Y of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
