The present technology relates to an image pickup element and an electronic device that can suppress a difference in sensitivity of light receiving units.The image pickup element includes a pixel array in which at least a first light receiving unit that receives light in a predetermined color and a second light receiving unit that receives light having a wavelength band of a band width narrower than a wavelength band of the predetermined color are arranged and, in a case where the pixel array is divided into four areas by a vertical line and a horizontal line, a position of the second light receiving unit in a first block, in which one or more of each of the first light receiving unit and the second light receiving unit are arranged, differs in each of the areas. The present technology can be applied to, for example, a CMOS image sensor.