ALICIA REGUEIRO-REN,JACOB SWIDORSKI,JIE CHEN,NICHOLAS A. MEANWELL,SING-YUEN SIT,YAN CHEN,ZHENG LIU
申请号：
BR112014010105
公开号：
BR112014010105A2
申请日:
2012.01.27
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. in particular, c-28 amines of c-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as hiv maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS. in particular, the following compounds are provided herein, including pharmaceutically acceptable salts thereof: a compound of formula i, a compound of formula ii, and a compound of formula iii. c-28 amines of c-3 modified betulinic acid derivatives as inhibitors of hiv maturation. Compounds having drug and bio-effect properties, their pharmaceutical compositions and methods of use are mentioned. in particular, c-28 amines of c-3 modified betulinic acid derivatives having unique antiviral activity are provided as hiv maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS. in particular, the following compounds are provided herein, including pharmaceutically acceptable salts thereof: a compound of formula i, a compound of formula ii, and a compound of formula iii.abstract compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. in particular, c-28 amines of c-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as hiv maturation inhibitors. these compounds are useful for the treatment of hiv and aids. in particular, the following compounds are provided herein, including pharmaceutically acceptable salts thereof: a compound of formula i , a compound of formula ii , and a compound of formula iii . ____________________________________________________________________________ tradução do resumo resumo patente de invenção: "aminas de c-28 de derivados de ácido betulínico modificado por c-3 como inibidores de maturação de hiv". compostos tendo fármaco e propriedades de bioefeito, suas composições farmacêuticas
