MO, Y. JOSEPH,毛 Y 约瑟夫,毛 Y 約瑟夫,CHU, CHUN KWONG,朱振光,朱振光
申请号：
TW105106088
公开号：
TW201634482A
申请日:
2016.02.26
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The invention is related to fusion proteins of human somatostatin (e.g., SST-14 or SST-28) and human serum albumin, comprising a region at least 85% homologous to human somatostatin and a region at least 85% homologous to human serum albumin or a region with a partial amino acid sequence of human serum albumin, wherein linker peptide sequences may be present between somatostatin and somatostatin moieties or somatostatin and albumin moieties. Also disclosed are constructs wherein the somatostatin moiety contains multiple tandem repeats of a somatostatin sequence. In selected embodiments, the orientation of the somatostatin and albumin moieties can be varied, and such sequences may impact the binding and efficacy of the disclosed fusion proteins. Also disclosed are methods of making and using the aforementioned constructs.本發明係關於人類體抑素(例如,SST-14或SST-28)與人類血清白蛋白之融合蛋白,其包含與人類體抑素至少85%同源之區域及與人類血清白蛋白至少85%同源之區域或具有人類血清白蛋白之部分胺基酸序列之區域,其中連接子肽序列可存在於體抑素與體抑素部分之間或體抑素與白蛋白部分之間。亦揭示構築體,其中該體抑素部分含有體抑素序列之多個串聯重複段。在所選實施例中,體抑素及白蛋白部分之取向可改變,且此等序列可影響該等所揭示融合蛋白之結合及效能。亦揭示上文所提及之構築體之製備及使用方法。
