The present invention and peoples growth hormone release inhibiting hormone fusion protein (for example, SST-14 or SST-28) and human serum albumins, including the homologous peoples growth hormone release inhibiting hormone in region at least 85%, with homologous, the human serum albumins in region at least 85%, or the amino acid sequence that will there is local human serum albumins, whereinThere may be some growth chalones and Albumin in Partial of somatostatin and growth hormone release inhibiting hormone between the peptide sequence of the connector. It is also disclosed that construct, wherein multiple tandem sequence repeats somatostatin sequences are contained in growth hormone release inhibiting hormone part. In selected embodiment, oriented growth chalone and Albumin in Partial can change, and above-mentioned sequence can influence the open fusion protein of binding and effect. It also discloses and makes and uses above-mentioned construct. It is compared in vitro with extended plasma half-life when the fusion protein of growth hormone release inhibiting hormone albumin shows to be incubated in the rat plasma of enhancing stability and discharges somatostatin in vivo.
