crystalline solid forms of n- {4 - [(6,7-dimethoxyquinolin-4-yl) oxy] phenyl} -n '- (4-fluorophenyl) cyclopropane-1,1-dicarboxamide, preparation processes and methods of use
AFTAB, DANA, T.,GALBRAITH, JANA,GUZ, NATHAN,HAMILL, NOEL,LAU, STEPHEN,SHAH, KHALID,WALKER, TRACY,YAU, SIMON
申请号：
BR112016018450
公开号：
BR112016018450A2
申请日:
2015.02.16
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The invention relates to novel crystalline solid forms of the chemical compound N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib.
