Crystalline solid forms of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use
AFTAB, Dana T.,GUZ, Nathan,LAU, Stephen,HAMILL, Noel,WALKER, Tracey,GALBRAITH, Jana,YAU, Simon,SHAH, Khalid
申请号：
AU2019226302
公开号：
AU2019226302A1
申请日:
2019.09.10
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
#$%^&*AU2019226302A120190926.pdf#####Abstract The invention relates to novel crystalline solid forms of the chemical compound N{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl) cyclopropane-1,1dicarboxamide (Compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma. The crystalline solid forms can be used to make the L-malate salt of cabozantinib. 50
