DIETRICH, RANGO DR.,LINDER, RUDOLF DR.,DIETRICH, Rango dr.,LINDER, Rudolf dr.
申请号：
YUP37703
公开号：
RS52024B
申请日:
2001.11.17
申请国别(地区):
YU
年份:
2012
代理人:
摘要：
The invention relates to compounds of the general formula (I) wherein R1 is lower alkyl, lower alkoxy, pyridinyl, pyrimidinyl, phenyl, -S-lower alkyl, -S(O)2-lower alkyl, -N(R)-(CH2)n-N(R)2, -O-(CH2)n-N(R)2, -N(R)2, or a cyclic tertiary amine which may contain one additional heteroatom, selected from N, O or S, and wherein this group may be connected with the pyrimidine ring via the linker -O(CH2)n-； R2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl； R3/R3' is, independently from each other, hydrogen or lower alkyl； R4 is independently from each other halogen, trifluoromethyl or lower alkoxy； X is-C(O)N(R) or -N(R)C(O)-； Y is -O-,-S-,-SO2-, or -N(R)-； n is 1,2,3 or 4； and m is 0,1 or 2； and to pharmaceutically acceptable acid addition salts thereof. They have a good affitity to the NK1 receptor and they are therefore suitable in the treatment of diseases, related to this receptor.Postupak za proizvodnju preparata sušenog putem zamrzavanja koji sadrži 5-difluorometoksi-2-[(3,4-dimetoksi-2-piridinil)metilsulfinil]-1H-benzimidazol (pantoprazol), njegovu so, solvat pantoprazola ili njegovu so, naznačen time, što se vrši sušenje putem zamrzavanja vodenog rastvora pantoprazola, njegove soli, solvata pantoprazola ili njegove soli, etilendiamin tetrasirćetne kiseline i/ili njene pogodne soli i natrijum-hidroksida i/ili natrijum-karbonata. Prijava sadrži još 20 patentnih zahteva.
