GLAXOSMITHKLINE IP DEV LTD;GlaxoSmithKline Intellectual Property Development Limited
发明人:
BURY, Michael Jonathan,CASILLAS, Linda N.,CHARNLEY, Adam Kenneth,HAILE, Pamela A.,MARQUIS, Robert W.,MEHLMANN, John F.,ROMANO, Joseph J.,SINGHAUS, Robert R.,WANG, Gren Z.,BURY MICHAEL JONATHAN,BURY, MICHAEL JONATHAN,CASILLAS LINDA N,CASILLAS, LINDA N.,CHARNLEY ADAM KENNETH,CHARNLEY, ADAM KENNETH,HAILE PAMELA A,HAILE, PAMELA A.,MARQUIS ROBERT W,MARQUIS, ROBERT W., JR.,M
申请号：
ES12755475
公开号：
ES2609578T3
申请日:
2012.03.02
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound according to Formula (I): ** Formula ** in which: R1 is H, -SO2 (C1-C4 alkyl), -CO (C1-C4 alkyl) or (C1-C4 alkyl)； R2 is -SORa or -SO2Ra, in which Ra is a (C1-C6) alkyl, C3-C7 cycloalkyl, 4-7 membered heterocycloalkyl, aryl or heteroaryl group, optionally substituted in which: said (C1-alkyl) -C6) is optionally substituted with one or two groups each independently selected from the group consisting of cyano, hydroxyl, (C1-C6) alkoxy, (C1-C6) alkoxy (C2-C6) alkoxy, -CO2H, -CO2alkyl (C1-C4), -SO2 (C1-C4 alkyl), -CONH2, -CONH (C1-C4 alkyl), -NHC (>； = O) (C1-C4 alkyl), -CON (C1-C4 alkyl) ( C1-C4 alkyl), -N (C1-C4 alkyl) (C (>； = O) (C1-C4 alkyl)), -SO2NH2, -SO2NH (C1-C4 alkyl), -NHSO2 (C1-C4 alkyl), -SO2N (C1-C4 alkyl) (C1-C4 alkyl), -N (C1-C4 alkyl) (SO2 (C1-C4 alkyl)), amino, (C1-C4 alkyl) amino-, (C1-C4 alkyl) (C1-C4 alkyl) amino-, C3-C7 cycloalkyl, phenyl, 5-6 membered heteroaryl, 9-10 member heteroaryl, 4-7 member heterocycloalkyl and (phenyl) (C1-C4 alkyl) amino-, in which said C3-C7 cycloalkyl, phenyl, (phenyl) (C1-C4 alkyl) amino-, heteroa 5-6 membered ryl, 9-10 membered heteroaryl or 4-7 membered heterocycloalkyl is optionally substituted with 1-3 groups each independently selected from the group consisting of halogen, -CF3, (C1-C4) alkyl, hydroxyalkyl (C1-C4) and alkoxy (C1-C4), said cycloalkyl (C3-C7) or 4-7 membered heterocycloalkyl is optionally substituted with 1-3 groups each independently selected from the group consisting of halogen, -CF3 , hydroxyl, amino, (C1-C4 alkyl) amino-, (C1-C4 alkyl) (C1-C4 alkyl) amino-, (C1-C4) alkyl, phenylalkyl (C1-C4) -, hydroxyalkyl (C1-C4) -, oxo, (C1-C4) alkoxy and (C1-C4) alkoxy (C2-C4) alkoxy -, and said aryl or heteroaryl is optionally substituted with 1-3 groups each independently selected from the group consisting of halogen, -CF3, hydroxyl, amino, (C1-C4) alkyl, phenylalkyl (C1-C4) -, hydroxyalkyl (C1-C4) - and (C1-C4) alkoxy, and wherein said heteroaryl is a 5-6 heteroaryl members or a 9-10 membered
