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NOVEL COCHLEATE FORMULATIONS
专利权人:
Rutgers; The State University of New Jersey
发明人:
Leila Zarif,Tuo Jin,Ignacio Segarra,Raphael J. Mannino
申请号:
US14145268
公开号:
US20140220109A1
申请日:
2013.12.31
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
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