Brian Alvin Johns,Takashi Kawasuji,Teruhiko Taishi,Yoshiyuki Taoda
申请号：
US11919386
公开号：
US08129385B2
申请日:
2006.04.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is directed to a class of substituted 5-hydroxy-3,4,6,9,9a,10-hexahydro-2H-1-oxa-4a,8a-diaza-anthracene-6,10-diones useful as anti-HIV agents. The compounds have the formula:Z═O； R20, R21, R22, R23, R24 and R25 independently are hydrogen, C1-C8 alkyl, (C6-C14)aryl-(C1-C8)alkyl, C6-C14 aryl, or alkoxy； the stereochemistry of an asymmetric carbon represented by * shows R- or S-configuration, or a mixture thereof； RX is hydrogen； R14 is hydrogen or optionally substituted lower alkyl； R3 is hydrogen； R1 is hydrogen or lower alkyl； R is halogen； and m is 1, 2 or 3； or a pharmaceutically acceptable salt thereof.
