Compound of the formula ** Formula ** in which R1 represents a group of the formulas ** Formula ** in which * is the point of attachment to the carbonyl group, X represents an oxygen atom, a sulfur atom or CH -R6, wherein R6 represents hydroxy, R2 represents hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl or phenyl, wherein alkyl and cycloalkyl may be substituted with a substituent selected from the group consisting of hydroxy, methoxy, cyano, hydroxycarbonyl, aminocarbonyl , methylsulfonyl, difluoromethoxy and trifluoromethoxy, or wherein alkyl and cycloalkyl may be substituted with 1 to 3 fluorine substituents, R3 represents hydrogen or C1-C4 alkyl, or R2 and R3 together with the carbon atom to which they are attached form a ring cyclopropyl, a cyclobutyl ring or a cyclopentyl ring, wherein the cyclobutyl ring and the cyclopentyl ring may be substituted with a hydroxy substituent, R4 represents hydrogen or C1-C6 alkyl, wherein alkyl may be substituted with a hydroxy substituent, R5 represents C1-C4 alkyl, or R4 and R5 together with the carbon atom to which they are attached form a cyclopropyl ring, a cyclobutyl ring or a cyclopentyl ring, wherein the ring cyclobutyl and the cyclopentyl ring may be substituted with a hydroxy substituent, R7 represents hydrogen or C1-C6 alkyl, where alkyl may be substituted with a hydroxy or cyano substituent, or where alkyl may be substituted with 1 to 3 fluorine substituents , R8 represents hydrogen, R9 represents hydrogen or C1-C6 alkyl, wherein alkyl may be substituted with a hydroxy or cyano substituent, or wherein alkyl may be substituted with 1 to 3 fluorine substituents, R10 represents hydrogen, R11 represents C1- alkyl C4, wherein alkyl may be substituted with a hydroxy substituent, R12 represents hydrogen or C1-C4 alkyl, or R11 and R12 together with the carbon atom to which they are attached they form a cyclopropyl ring, a cyclobutyl ring or a cyclopentyl ring, wherein the cyclobutyl ring and the cyclopentyl ring may be substitute
