The invention relates to anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.本發明係關於抗-因子D抗體變異體、其產生及其在製備用於治療與過度或失控性補體活化相關之疾病及病症之組合物及藥劑中的用途。