The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.本發明係關於人類化抗人類因子D單株抗體、其核酸及胺基酸序列、包含該等抗體之細胞及載體以及其在製備用於治療與過度或不受控補體活化相關疾病及病症之藥物中之用途。該等抗體可用於診斷、預防及治療疾病。
