人類化之抗-因子D抗體及其用途农业专利-农业专业知识服务系统

发明人:: WU, HERREN,吴　海伦,吳　海倫,SINGH, SANJAYA,幸　山加亚,幸　山加亞,FUNG, SEK CHUNG,冯　协中,馮　協中,AN, LING-LING,安　玲　玲,LOWMAN, HENRY B.,罗门　亨利Ｂ,羅門　亨利Ｂ,KELLEY, ROBERT F.,凯力　罗伯特Ｆ,凱力　羅伯特Ｆ,吴海伦,吳海倫,幸山加亚,幸山加亞,冯协中,馮協中,安玲玲,罗门亨利B,羅門亨利B,凯力罗伯特F,凱力羅伯特F

摘要：: The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.本發明係關於人類化抗人類因子D單株抗體、其核酸及胺基酸序列、包含該等抗體之細胞及載體以及其在製備用於治療與過度或不受控補體活化相關疾病及病症之藥物中之用途。該等抗體可用於診斷、預防及治療疾病。